Kikuchi-Fujimoto病

Kikuchi-Fujimoto病（KFD）临床上主要表现为淋巴结肿大及发热，其中40%的患者可有皮肤受累。淋巴结活检组织病理学检查可见含核碎屑的凝固性坏死灶。临床上常被误诊为结核、系统性红斑狼疮及血液系统肿瘤等疾病。KFD症状和体征常在1～ 4个月内消失且较少复发，一般只需对症支持治疗，及时明确诊断以避免过度治疗十分重要。本文对KFD的发病机制、临床表现、诊断及治疗进行综述。

Kikuchi-Fujimoto disease

Kikuchi-Fujimoto disease (KFD) is characterized by lymphadenopathy and fevers. Skin lesions are seen in about 40% of the patients. The lymph node biopsy specimen shows coagulative necrosis with abundant karyorrhectic debris. KFD is often misdiagnosed as tuberculosis, systemic lupus erythema and hematological malignancies. The symptoms of the disease usually resolve spontaneously in 1~ 4 months with a low recurrence rate. Only symptomatic treatment is needed and definitive diagnosis to avoid excessive treatment is necessary. The pathogenesis, clinical manifestations, diagnosis and treatment of KFD are reviewed in this article.