半乳糖凝集素与皮肤病研究进展

半乳糖凝集素家族是一类内源性凝集素家族，与含β-半乳糖苷残基的多聚糖具有高亲和力，目前已有15个半乳糖凝集素家族成员被发现，其广泛分布于上皮细胞和免疫细胞，参与细胞的生长分化、细胞间的粘附、细胞信号转导及细胞凋亡等多种细胞活动。其中，半乳糖凝集素-1，-3，-7，-9，-12参与皮肤肿瘤、创面愈合、银屑病、硬皮病、系统性红斑狼疮、特应性皮炎、白癜风等多种皮肤病的疾病进程，有望作为疾病发展和预后的生物标记物。本文对近年来半乳糖凝集素-1，-3，-7，-9，-12及相关皮肤病研究进展进行综述。

Update of galectins and skin diseases

Galectins is a family of endogenous lectins that preferentially bind to β-galactosides. Fifteen galectins family members have been identified, which is widely distributed in epithelial cells and immune cells. Galectins are involved in many cell activities including cell growth and differentiation, adhesion, signal transduction and apoptosis. Galectin-1, -3, -7, -9, -12 may be associated with skin tumors, wound healing, psoriasis, scleroderma, systemic lupus erythematosus, atopic dermatitis and vitiligo. The update of galectin-1, -3, -7, -9, -12 and related dermatoses is reviewed.