| UVB对成纤维细胞中IFI16表达的影响 |
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| 引用本文： | 马慧敏,赵琦,刘玮. UVB对成纤维细胞中IFI16表达的影响[J]. 中国麻风皮肤病杂志, 2018, 34(1): 25-28 |
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| 作者姓名： | 马慧敏 赵琦 刘玮 |
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| 作者单位： | 1、首都医科大学电力教学医院 皮肤科 北京 1000732、空军总医院 皮肤病医院 刘玮 北京 100042 |
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| 摘 要： | 目的：检测UVB辐射后成纤维细胞中IFI16的表达水平。方法：用亚毒性UVB诱导成纤维细胞老化，并用real-time PCR和western bolt方法检测IFI16 mRNA 和蛋白质表达水平的变化。结果：UVB照射后诱导的老化成纤维细胞中IFI16 mRNA和蛋白质分别为空白对照组的2.11±0.45倍和1.59±0.23倍。结论： UVB诱导的成纤维细胞中IFI16表达水平升高，IFI16可能参与细胞光老化的进程。
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| 关 键 词： | IFI16 细胞光老化 |
Up-regulation of IFI16 in fibroblasts irradiated by UVB |
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| MA Huimin,LIU Wei.. Up-regulation of IFI16 in fibroblasts irradiated by UVB[J]. China Journal of Leprosy and Skin Diseases, 2018, 34(1): 25-28 |
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| Authors: | MA Huimin LIU Wei. |
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| Affiliation: | 1 Department of Dermatology, Electric Teaching Hospital of Capital Medical University，Beijing 100137, P.R. China;2 Department of Dermatology, the General Hospital of the Air Force, Beijing 1000142, P.R. China |
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| Abstract: | Objective: To detect the level of IFI16 in the fibroblasts irradiated by UVB. Methods: The fibroblasts were irradiated by triplicate UVB, and the levels of IFI16 mRNA and protein were detected by RT-PCR and western blot. Results: The levels of IFI16 mRNA and protein in the fibroblasts irradiated by UVB were 2.11±0.45 and 1.59±0.23 times more than those in normal fibroblasts (P<0.05). Conclusion: The level of IFI 16 was increased in the fibroblasts irradiated by UVB. IFI 16 may be involved in the process of fibroblasts photoageing. |
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