血小板活化因子及其乙酰水解酶与荨麻疹的相关性研究

目的： 明确人体血清血小板活化因子（PAF）及血小板活化因子乙酰水解酶（PAF-AH）水平与荨麻疹发病的相关性。方法： 收集荨麻疹患者及正常对照者的血清样本，对荨麻疹患者进行病情严重程度评分（UAS），利用ELISA法对样本中PAF及PAF-AH水平进行测定。结果： 共有32例急性和32例慢性荨麻疹患者入选，血清PAF水平分别为430.4 pg/mL及391.6 pg/mL，高于32例正常对照(224.5±31.67pg/mL)，差异均具有统计学意义(均P<0.05)。急、慢性荨麻疹患者血清PAF-AH水平与正常对照组相比无统计学差异。血清PAF水平与急、慢性荨麻疹患者UAS评分存在正相关(均P<0.05)，PAF-AH水平与急、慢性荨麻疹病情严重程度评分均无明显相关性（均P>0.05）。结论：PAF可能与急、慢性荨麻疹的发病有关。

Correlation of platelet-activating factor and its acetylhydrolase status in urticaria

Objective: To determine the correlation of platelet-activating factor (PAF) and platelet-activating factor acetylhydrolase (PAF-AH) status in the patients with in acute/chronic urticaria. Methods: Serum samples from patients and normal controls were collected; Urticaria activity score (UAS) of the patients were assessed.. The level of PAF and PAF-AH were detected by ELISA. Results: Thirty two patients with acute and 32 with chronic urticaria,,and 32 normal controls were recruited into the study. The PAF level in the patients with acute urticaria and chronic urticaria were 430.4pg/mL and 391.6pg/mL respectively, which were higher than that in the controls (224.5±31.67pg/mL), with significant differences (Ps<0.05). There were no significant difference of PAF-AH between urticaria patients and controls (Ps>0.05). Conclusions: PAF may be associated with the onset of urticaria.