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Dermatologic side effects induced by new angiogenesis inhibitors
Authors:Sibaud Vincent  Garrido-Stowhas Ignacio  Cottura Ewa  Chevreau Christine
Institution:Institut Claudius-Regaud, Toulouse cedex, France. sibaud.vincent@claudiusregaud.fr
Abstract:While new anticancer angiogenesis inhibitors present a well-tolerated safety profile, they are not without adverse events. The signaling pathways and/or receptors inhibited by these new drugs are often physiologically expressed in the skin and/or hair follicle and cutaneous toxicity is on the forefront. This article reviews the main dermatologic adverse events induced by these targeted anticancer therapies with a partial or exclusive antiangiogenic activity: sorafenib, sunitinib, pazopanib, vandetanib, everolimus, temsirolimus or bevacizumab.
Keywords:effets indésirables cutanés  thérapies ciblées antiangiogéniques  pazopanib  vandétanib  inhibiteurs mTOR  sorafénib  cutaneous adverse events  angiogenesis inhibitors  pazopanib  vandetanib  mTOR inhibitors  sorafenib
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