首页 | 本学科首页   官方微博 | 高级检索  
     


Concurrent lipopolysaccharide enhances chemotactic response of human polymorphonuclear leukocytes to bacterial chemotaxin
Authors:H. R. Creamer  N. Hunter  W. W. Bullock  W. L. Gabler
Affiliation:(1) Department of Oral Microbiology/Immunology, School of Dentistry, Oregon Health Sciences University, 97201-3097 Portland, OR;(2) Department of Biochemistry, School of Dentistry, Oregon Health Sciences University, 97201-3097 Portland, OR;(3) The Dental Research Institute, Surry Hills, NSW, Australia
Abstract:Polymorphonuclear neutrophil (PMN) function is thought to be critical in resistance to infectious agents and this implies that the PMN must be able to migrate into, and to function in, environments that may have high levels of bacterial lipopolysaccharide (LPS). Therefore, we have evaluated the effect of LPS on the in vitro migration of PMNs. Our data reveal that the human PMN is resistant to the deleterious effects of high levels of LPS, that in high concentrations LPS is, itself, a direct chemoattractant for PMNs, and that PMN migration toward a bacterial chemotaxin is enhanced if LPS is also present. Such capabilities suggest that the PMN may be uniquely qualified to migrate into microenvironments that are rich in LPS.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号