帕金森病血抗氧化系统变化及其临床意义

为探讨帕金森病（PD）患者体内抗氧化系统水平及其在PD发病中的作用，对70例PD患者血浆维生素C（P－VC）、维生素E（P－VE）、血浆及红细胞超氧化物歧化酶（P－SOD，E－SOD）、血浆与红细胞过氧化脂质（P－LPO，E－LPO）的水平进行了检测并与正常对照组比较。结果表明：PD组P-VC、P-VE水平及P-SOD、E-SOD活性均比正常对照组显著降低，而P-LPO、E-LPO则显著增高，并且P-VC、P-VE、E-SOD与病情和病程呈负相关，提示抗氧化系统缺陷及内源性氧自由基堆积与PD发病有密切关系。

The Changes of Blood Antioxidant System in Parkinson''s Disease and Its Clinical Significance

To explore blood levels of antioxidant system in patients with Parkinson's disease (PD)and its possible role in the pathogenesis of PD, plasma levels of vitamin E and vitamin C (P-VE, P-VC) and erythrocyte levels of superoxide dismutase (P-SOD, E-SOD) and lipoperox-ides (P-LPO, E-LPO) were measured in 70 PD patients, using 70 healthy volunteers as thecontrol group- The results showed that, levels of P-VE and P-VC as well as activity of P-SOD and E-SOD l0wered significantly as compared with the normal controls, while the con-tents of P-LPO and E-LPO were increased. ln addition, P-VE, P-VC and E-SOD levelswere inversely correlated with severity and duration of the disease. The results suggestedthat PD patients might have defects in antioxidant system, which could cause the accumula-tion of endogenous free radical and the degeneration of nigra neurons in the substantia nigra.