| 雌激素干预早产儿视网膜病变的研究进展 |
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| 引用本文： | 范海燕,倪卫杰.雌激素干预早产儿视网膜病变的研究进展[J].国际眼科杂志,2008,8(7):1448-1450. |
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| 作者姓名： | 范海燕 倪卫杰 |
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| 作者单位： | 上海交通大学医学院附属第三人民医院眼科,中国上海市,201900 |
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| 摘 要： | 早产儿视网膜病变(ROP)是一种以视网膜新生血管为主要病理改变的疾病,是儿童致盲的主要原因之一。目前主要采取激光或手术治疗,损伤较大且效果不理想,因此寻找有效的药物途径来预防ROP的发生成为研究热点。血管内皮生长因子(VEGF)是一种已知的促新生血管生成物质,在ROP的发病过程中起关键作用,雌激素通过调控VEGF减少新生血管生成,从而防止ROP的发生。本文将围绕早产儿视网膜病变新生血管,VEGF以及雌激素三者之间的关系进行综述。
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| 关 键 词： | 早产儿视网膜病变 新生血管 雌激素 血管内皮生长因子 |
Advance on estrogen intervening retinopathy of prematurity |
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| Hai-Yan Fan,Wei-Jie Ni.Advance on estrogen intervening retinopathy of prematurity[J].International Journal of Ophthalmology,2008,8(7):1448-1450. |
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| Authors: | Hai-Yan Fan Wei-Jie Ni |
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| Institution: | Department of Ophthalmology, the Third People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201900, China |
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| Abstract: | Retinopathy of prematurity (ROP) is a neovascula-rization and fiber tissue proliferative disease related with receiving oxygen therapy. ROP is one of the major causes of children blindness. Operation is presently the main therapeutic method for ROP, but the result is not satisfactory. So searching for effective medicine to pre-vent ROP is becoming a hotspot. Vascular endothelial growth factor is the most enhancing factor of retinal neovascularization at present, which plays a key role in the process of ROP. Estrogen could suppress ROP neovascularization through modulating VEGF expression. The main aim of this review is to introduce the rela-tionship of ROP neovascularization, VEGF and estrogen. |
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| Keywords: | retinopathy of prematurity new vessels estrogen vascular endothelial growth factor |
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