Cytokine-secreting tumor cell vaccines |
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| Authors: | Mach N Dranoff G |
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| Affiliation: | Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. |
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| Abstract: | Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes. |
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