Stimulation of folliculo-sebaceous proliferations by neurofibromas: a report of two cases |
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| Authors: | Emilio del,Rio ,Evaristo Sá nchez Yus,Pilar Simó n,Hugo A. Vá zquez Veiga |
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| Affiliation: | Division of Dermatology, Hospital de Conxo, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela;Department of Dermatology, Hospital Universitario San Carlos, Madrid;Department of Cell Biology, Facultad de Medicina, Universidad Complutense, Madrid, Spain |
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| Abstract: | Two unrelated patients, a woman aged 44 and a man aged 56, with a type I neurofibromatosis, showed comedo-like formations at the top of some neurofibromas. One of them was excised in each case and they were studied histopathologically. The comedo-like formation of the first case mimicked the epithelial component of a fibrofolliculoma, and that of the second case had the structure of a primary late microcomedo and showed also anagen hair differentiation in the form of a follicular bulb and papilla. Both events are considered to be the result of a stimulation phenomenon and to reflect the essential role of the stroma in many cutaneous epithelial hyperplasias, hamartomas and possibly in some neoplasms. |
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