单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病疗效观察

目的观察单唾液酸四己糖神经节苷脂（GM1）治疗新生儿缺氧缺血性脑病的疗效。方法将新生儿缺氧缺血性脑病患儿100例随机分为两组：对照组（50例）在对症、支持治疗基础上采用给予胞二磷酸胆碱治疗,观察组（50例）在对症、支持治疗基础上给予神经节苷脂进行治疗。比较两组的疗效、头颅CT变化、新生儿神经行为评分（NBNA）等指标。结果治疗后观察组与对照组相比较,观察组临床症状体征恢复时间、脑CT恢复正常率和总有效率均优于对照组（P〈0.05）,治疗后NBNA评分,观察组均高于对照组（P〈0.05）。结论神经节苷脂对于新生儿缺氧缺血性脑病患儿的治疗具有较好的效果,值得临床推广使用。

Clinical observation on curative effect of monosialoganglioside in treatment of neonatal hypoxic-ischemic encephalopathy

Objective To observe the curative effect on monosialoganglioside （ GM1 ） in treatment of neonatal hypoxic ischemic encephalopathy.Methods A hundred cases of HIE were randomly divided into two groups：the control group treated with routine therapy and citicoline, the observation group treated with routine therapy and GM1.To compare two groups effects, CT changes, the scores of neonatal behavioral neurological assessment （ NBNA） .Results After treatment, the recovery time of the clinical symptom and return to normal after treatment in the CT rate and the treatment efficiency of the observation group was significantly higher compared with the control group（P〈0.05）, Neonatal behavioral neurological assessment score was higher in the observation group than that in the control group（P〈0.05）.Conclusions The better therapeutic effect of treating HIE with GM1,and it is worthy of clinical use.