| 人参三醇组甙抗辐射作用的研究 |
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| 引用本文： | 李校坤,林灼锋,黄亚东,邓青,许华.人参三醇组甙抗辐射作用的研究[J].中药材,2002,25(11):805-808. |
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| 作者姓名： | 李校坤 林灼锋 黄亚东 邓青 许华 |
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| 作者单位： | 暨南大学医药生物技术研究开发中心,广州,510632 |
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| 基金项目： | 广东省自然科学重点基金(编号:C010502) |
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| 摘 要： | 目的:探讨人参三醇组甙(panaxatriol)的辐射防护作用,为开发相关的护肤产品提供实验依据。方法:小鼠接受X射线照射前用人参三醇组甙灌胃,照射后3h取小鼠骨髓细胞制备染色体标本,观察骨髓细胞染色单体型和染色体型畸变以及畸变细胞数。结果:辐照前给予人参二醇组甙200～400 mg/kg可降低辐射诱发染色体和细胞的畸变;给药剂量和给药时间与防护效应呈正相关,照射剂量与防护效应呈负相关。结论:人参三醇组甙对骨髓细胞染色体具有较好的辐射防护作用。
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| 关 键 词： | 人参三醇组甙 染色体畸变 辐射防护 |
| 修稿时间： | 2002年4月26日 |
Study on Antiradiation Effect of Panaxatriol |
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| Li Xiaokun,Lin Zhuofeng,Huang Yadong,Deng Qing,Xu Hua.Study on Antiradiation Effect of Panaxatriol[J].Jorunal of Chinese Medicinal Materials,2002,25(11):805-808. |
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| Authors: | Li Xiaokun Lin Zhuofeng Huang Yadong Deng Qing Xu Hua |
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| Institution: | Jinan University, Guangzhou 510632. |
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| Abstract: | Objective: To study antiradiation effect of panaxatriol (PT) and to provide an experiment basis for developing relative radiation-resistant skin care products. Methods: Mice were treated with PT or normal saline (the control group) before X-ray irradiation and were killed 3 hours after irradiation. The chromosome samples of bone marrow cells were prepared to observe the number of chromosme aberrations and chromalid mutation as well as aberrant cells. Results: PT can reduce the frequency of chromatid mutative induced by X-ray. Antiradiation effect was positively correlated with the dose of Pf and the duration of drug, and negatively correlated with the dose of X-rays. Conclusion: IT has significant antiradiation effect. |
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| Keywords: | Panaxatriol Chromosome mutation Radiation-resistant |
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