| Abstract: | To analyse the outcome of patients with WHO grade II meningioma and identify factors that may influence recurrence and survival. Between January 2007 and September 2015, a retrospective search identified 194 WHO grade II meningiomas at the National Hospital for Neurology and Neurosurgery, London. Survival methods were implemented. 31 patients (16?%) had a previous history of grade I meningioma. The patients underwent a total of 344 surgical resections and 43.3?% received radiotherapy. 55 patients (28.4?%) had been re-operated on for a WHO grade II meningioma relapse. Median follow-up was 4.4 years. At the end of the study, 75 patients (40.1?%) had no residual tumour on the last scan. Surgical recurrence free survival at 5 years was 71.6, 95?% CI [63.5, 80.8]. Secondary grade II meningioma (HR?=?2.29, p?=?0.010), and, Simpson resection grade 1, 2 and 3 vs. 4 and 5 (HR?=?0.57, p?=?0.050) were associated with the surgical recurrence-free survival. 32 died from meningioma (16.5?%). Overall survival probability at 5 years was 83.2, 95?% CI [76.6, 90.4]. Age at diagnosis (HR?=?0.22, p?p?=?0.001), tumour location (HR?=?0.19, p?p?=?0.010) were independently associated with the overall survival. Patients who received radiotherapy demonstrated neither a reduced risk of recurrence nor a longer overall survival (p?=?0.310). In our series shorter survival correlated with older age, increased mitoses, progression from grade I to II and location. We were not able to demonstrate a significant improvement in any of the clinical outcomes after radiotherapy. |
