靶向uPA-uPAR系统在肿瘤治疗中的研究进展

uPA-uPAR系统在多种肿瘤组织中表达增高,该系统不但可促进细胞外基质蛋白降解,而且可以与玻连蛋白、整合素等结合参与细胞内信号转导,从而介导肿瘤的发生与发展。近年来,一系列靶向uPA-uPAR系统的方案在肿瘤治疗中取得了显著效果,并且其中部分药物已经进入临床试验阶段,为肿瘤的靶向治疗提供了新思路。本文拟从靶向uPA-uPAR系统的基因治疗、药物治疗和免疫治疗等方面的研究进展进行综述。

Research Progress of Targeting uPA-uPAR System in Tumor Therapy

The uPA-uPAR system is highly expressed in various tumor tissues. This system can promote the degradation of extracellular matrix proteins, as well as combine with vitronectin and integrin to transmit intracellular signal transduction. Subsequently, it mediates the occurrence and development of tumors. In recent years, a series of therapeutic programs that target this system has achieved notable results in tumor treatment, and some of them have been under the clinical trial stage, thus providing new ideas for tumor targeted therapy. Therefore, this paper intends to provide a review of research progress on the gene therapy, drug therapy, and immunotherapy targeting uPA-uPAR system.