定量分析糖尿病视网膜病变患者视盘周围视网膜和脉络膜血流灌注

目的 定量分析不同阶段糖尿病视网膜病变(DR)患者视盘周围视网膜和脉络膜变化。方法 对90例(90眼)患者进行横断面研究。受试者分为3组：对照组(n=30)、无DR(NDR)组(n=30)和非增生型DR(NPDR)组(n=30)。比较不同组别受试者视盘周围视网膜血流灌注(RP)、视网膜血管密度(RVD)、视网膜神经纤维层厚度(RNFL)、脉络膜血管体积(CVV)、脉络膜血管指数(CVI)、脉络膜厚度(CT)。结果 与对照组相比，NDR组患者RP[(13.16±0.98)mm²]、RVD[(61.80±5.29)%]、RNFL[(75.41±11.19)μm]均显著降低(均为P<0.05),NPDR组患者RP[(11.70±1.53)mm²]、RVD[(56.92±5.61)%]、RNFL[(68.77±9.61)μm]和CVI(0.16±0.05)均降低(均为P<0.05)。与NDR组相比，NPDR组患者RP、RVD、RNFL和CVI均降低(均为P<0.05)。结论 NPDR期患者视盘周围视网膜和脉络膜血流已发生变化。扫频O...

Quantitative analysis of peripapillary retinal and choroidal blood perfusion in diabetic retinopathy patients

Objective　To conduct a quantitative analysis of the peripapillary retinal and choroidal blood perfusion changes at different stages of diabetic retinopathy (DR).
Methods　A cross-sectional study was carried out on 90 patients (90 eyes), which were classified into three groups: normal control group (n=30), non-diabetic retinopathy (NDR) group (n=30) and non-proliferative diabetic retinopathy (NPDR) group (n=30). The peripapillary retinal perfusion (RP), retinal vessel density (RVD), retinal nerve fiber layer (RNFL) thickness, choroidal vessel volume, choroidal vascularity index (CVI) and choroidal thickness in the three groups were measured and compared.
Results　Compared with the normal control group, the RP (13.16±0.98) mm², RVD (61.80±5.29)%and RNFL thickness (75.41±11.19) μm of the NDR group significantly decreased (all P<0.05); the RP (11.70±1.53) mm², RVD (56.92±5.61)%, RNFL thickness (68.77±9.61) μm and CVI (0.16±0.05) of the NPDR group significantly decreased (all P<0.05). Compared with the NDR group, the RP, RVD, RNFL thickness and CVI of the NPDR group significantly decreased (all P<0.05).
Conclusion　The peripapillary retinal and choroidal blood perfusion has changed in NPDR patinets. The swept source optical coherence tomography angiography can be used for early assessment of peripapillary vascular and nerve injury in DR patients.