脑白质高信号患者血清CX3CL1水平与认知功能障碍的关系

目的 探究脑白质高信号(white matter hyperintensity, WMH)患者血清趋化因子C-X3-C配体1(chemokine C-X3-C-motif ligand 1, CX3CL1),也被称作分形趋化因子(fractalkine, Fkn)的水平与认知功能障碍的相关性。方法 纳入2020年3月至2022年8月于新乡医学院第一附属医院神经内科影像学表现有WMH的脑小血管病(cerebral small vessel disease, CSVD)住院患者，收集患者一般临床资料、头颅核磁常规序列、生化指标，测定CX3CL1水平及评估简易认知量表(Mini-mental State Examination, MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment, MoCA),分析血清CX3CL1水平与WMH及认知功能的相关性。结果 共纳入152例受试者，根据MMSE结果分为认知功能正常组(77例)及认知功能障碍组(75例),平均年龄分别为(59.60±8.84)岁和(62.91±7.99)岁。相关性分析结果显示CX3CL1水平与视...

The relationship between serum CX3CL1 level and cognitive dysfunction in patients with white matter hyperintensity

Objective To explore the correlation between serum chemokine C-X3-C-motif ligand 1 (CX3CL1), also know as fractalkine (Fkn). levels and cognitive dysfunction in patients with white matter hyperintensity (WMH). Methods A total of 152 patients with cerebral small vessel disease (CSVD) enrolled in the First Affiliated Hospital of Xinxiang Medical University from March 2020 to August 2022 were collected. The general clinical data of patients, the routine sequence of cranial magnetic resonance imaging (MRI), biochemical indicators, serum CX3CL1 level, and Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) cognitive scores were collected, and the correlation between serum CX3CL1 levels and white matter hyperintensity and cognitive function was analyzed. Results A total of 152 participants were enrolled and divided into the group with normal cognitive function and the group of cognitive dysfunction according to the MMSE results, with the mean age of (59.60±8.84) years and (62.91±7.99)years, respectively. The correlation analysis results showed that CX3CL1 level and apparent space were negatively correlated with executive function, attention, and orientation.Regression analysis showed that CX3CL1 levels and white matter high-signal were risk factors for cognitive dysfunction. Receiver operating characteristic (ROC) curve analysis suggested that CX3CL1 levels may have potential predictive value for cognitive impairment. Conclusion Serum CX3CL1 levels and white matter hyperintensity are associated with cognitive function, and elevated serum CX3CL1 levels are risk factors for the development of cognitive dysfunction.