新生儿ABO溶血性黄疸检测C反应蛋白和降钙素原的临床意义

  目的  探讨检测C反应蛋白和降钙素原在新生儿ABO溶血性黄疸中的临床意义。  方法  选云南省某三甲医院2021年9月至2022年8月入院的ABO溶血性黄疸新生儿50例为观察组，同期的53例非溶血性病理性黄疸新生儿作为对照组，采用回顾性分析，对比分析2组患儿CRP、PCT水平、异常值检出率及感染发生率。  结果  观察组CRP水平[11.0000（9.1750，13.0025）]、PCT水平[0.6750（0.3175，2.9025）]、CRP异常值检出率（80%）、PCT异常值检出率（66%）、感染发生率（34%）均高于对照组CRP水平[1.5000（0.7000，7.5000）]、PCT水平[0.3200（0.2000，0.5850）]、CRP异常值检出率（41.5%）、PCT异常值检出率（32.1%）、感染发生率（11.3%），差异具有统计学意义（P<0.05）；CRP诊断新生儿病情进展的ROC曲线下面积（AUC）为0.664，灵敏度为91.3%，特异度为46.2%；PCT的AUC为0.711，灵敏度为82.6%，特异度为60.0%。  结论  CRP、PCT在新生儿ABO溶血性黄疸中可见明显升高，对其检测可尽早发现新生儿的病情进展情况，确保临床及时采取有效的治疗护理措施，对促进新生儿的早期康复具有重要意义。

Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice

  Objective  To investigate the clinical significance of c reactive protein and procalcitonin levels in neonatal ABO hemolytic jaundice .   Methods  A total of 50 ABO hemolytic jaundice neonates admitted to a grade III and class A hospital in Yunnan Province between September 2021and August 2022 were selected as the observation group and 53 newborns with non hemolytic and pathological jaundice were selected as the control group during the same period. Retrospective analysis was used to compare the levels of CRP and PCT, abnormal value detection rate and infection rate between the two groups.   Results  The levels of CRP [11.0000 （9.1750, 13.0025）], PCT [0.6750 （0.3175, 2.9025）], the detection rate of CRP abnormal value （80%）, the detection rate of PCT abnormal value （66%） and the incidence of infection （34%） in the observation group were higher than those in the control group [1.5000 （0.7000, 7.5000）, PCT level [0.3200 （0.2000, 0.5850）], CRP abnormal value detection rate （41.5%）, PCT abnormal value detection rate （32.1%） and infection incidence rate （11.3%）]. The differences were statistically significant （P < 0.05）. The area under the curve （AUC） of CRP in the diagnosis of neonatal progression was 0.664, the sensitivity was 91.3%, and the specificity was 46.2%. PCT had an AUC of 0.711, a sensitivity of 82.6%, and a specificity of 60.0%.   Conclusion  CRP and PCT can be significantly elevated in the early stage of neonatal ABO hemolytic jaundice, and its detection can detect the progress of the condition as early as possible, ensure the effectiveness of treatment and nursing measures taken in time in clinical practices, and have the great significance in promoting the early rehabilitation of newborns.