广州地区2017—2022年儿童呼吸道感染疾病负担及常见病原体流行特征

目的 分析与探讨广州地区儿童急性呼吸道感染的疾病负担与常见病原体流行特征。方法 以2017—2022上半年广州市某院收治的18 542例因急性呼吸道感染住院儿童为研究对象，采用间接免疫荧光法检测患儿血清中抗呼吸道合胞病毒(RSV)、腺病毒(ADV)、甲型流感病毒(IFV-A)、乙型流感病毒(IFV-B)、副流感病毒(PIV)、嗜肺军团菌(LP)、肺炎支原体(MP)及肺炎衣原体(CP)8项常见病原体IgM抗体。应用SPSS 22.0软件对数据进行统计分析。结果 18 542例急性呼吸道感染住院患儿平均住院7 d,平均住院总费用(中位数)为5 870.93元，～1岁患儿的住院总费用较高。18 542例患儿中，10 214例至少感染一种病原体，检出率为55.09%。男童检出率(52.31%)低于女童(59.77%),2017—2019年总检出率及混合感染率高于2020—2021年，高年龄组患儿总检出率及混合感染率高于低年龄组。4 973例为混合感染，以IFV-A+IFV-B+MP(1 033例)及IFV-A+IFV-B(1 022例)合并感染为主。病原体检出率前三分别为IFV-B(27.27...

Disease burden and epidemic characteristics of pathogens causing acute respiratory infection in children in Guangzhou City, 2017-2022

Objective To analyze the disease burden and epidemic characteristics of major pathogens causing acute respiratory infection (ARI) in children in Guangzhou City. Methods In 2017.01-2022.06, 18 542 hospitalized children with ARI in a hospital in Guangzhou City were taken as the research objects. Serum IgM antibodies against 8 common pathogens, including respiratory syncytial virus (RSV), adenovirus (ADV), influenza virus A (IFV-A), influenza virus B (IFV-B), parainfluenza virus (PIV), Legionella pneumophila (LP), Mycoplasma pneumo-niae (MP) and Chlamydia pneumoniae (CP), were detected by indirect immunofluorescence method. SPSS 22.0 software was used for statistical analysis. Results The average length of hospital stay of 18 542 children with ARI was 7 days, and the median of total hospitalization expense was 5 870.93 Yuan. The total hospitalization expense of children in the -1-year-old group was the highest. Among 18 542 children, 10 214 were infected with at least one pathogen, with a detection rate of 55.09%. Detection rate in boys (52.31%) was lower than that in girls (59.77%). The total detection rate and co-infection rate in 2017-2019 were higher than those in 2020-2021, and those in elder group were higher than in younger group. 4 973 children were co-infected, mostly with IFV-A+IFV-B+MP (n=1 033) and IFV-A+IFV-B (n=1 022). The top three pathogens with the highest detection rates were IFV-B (27.27%), MP (25.47%) and IFV-A (21.24%). Detection rate of RSV decreased with the increase of age, and detection rate of LP, CP and MP increased with the increase of age. Detection rate of ADV peaked in children in the -3-year-old group, while detection rates of IFV and PIV were the highest in the -5-year-old group. CP and RSV occurred frequently in summer and autumn, however, detection rates of the other 6 pathogens showed no obvious seasonal dependence. Conclusion Pathogens causing ARI in children in Guangzhou City have different age di-stribution and seasonal epidemic characteristics. Measures should be taken to reduce the incidence of pneumonia in younger children, so as to ease their disease burden of ARI.