N6-甲基腺嘌呤修饰在恶性肿瘤发生发展及治疗中的研究进展

近年来RNA修饰引起了全世界生物学家的广泛关注。到目前为止已发现170余个RNA修饰，其中N6-甲基腺嘌呤(m6A)是mRNA最主要的修饰方式之一。它调节RNA的剪接、转位、翻译和稳定性，在细胞的生长、分化和代谢中起着至关重要的作用。作为一种动态、可逆的修饰，m6A的表达水平受RNA甲基转移酶、去甲基酶以及m6A结合蛋白的共同调节。越来越多的研究表明m6A基因修饰与人类癌症的发生发展关系密切。本文就m6A异常修饰在多种恶性肿瘤发生发展及治疗中的研究进展进行综述，旨在为癌症治疗提供新的思路。

Research progress of N6-methyladenine modification in the occurrence,development and treatment of malignant tumors

In recent years,RNA modifications are gaining the interest of biologist worldwide.Till date,more than 170 modifications has been reported.Among these types，N6-methyladenosine(m6A) modification is the predominant mRNA modification,which regulates RNA splicing,translocation,stability and translation.m6A modification plays critical roles in the growth,differentiation and metabolism of cells.As a dynamic and reversible modification,the level of m6A is regulated by RNA methyltransferases,demethylases and m6A-binding proteins.More and more researches have implicated the correlation between m6A modification and human cancers.In this review,we summarize the research progress of m6A abnormal modification in the occurrence, development and treatment of various malignant tumors,in order to provide a new thought in anti-cancer therapy.