鸢尾素与新诊断2型糖尿病的相关性研究

目的 探讨鸢尾素（irisin）与新诊断2型糖尿病（T2DM）的相关性。方法 纳入40例新诊断的T2DM患者作为T2DM组，40例健康体检者作为对照（NC）组。收集并测量2组一般临床指标、代谢指标、血清炎性因子白细胞介素（IL）-1β、IL-6、肿瘤坏死因子（TNF）-α、干扰素（IFN）-γ及irisin水平，比较2组上述指标水平的差异，分析irisin与上述指标的相关性。Logistic回归分析irisin与新诊断T2DM的关系。结果 与NC组相比，T2DM组血清炎性因子IL-1β、IL-6、TNF-α、IFN-γ水平明显升高，irisin水平明显下降（P<0.05）。irisin与空腹血糖、餐后2 h血糖、糖化血红蛋白、稳态模型胰岛素抵抗指数、IL-1β及IFN-γ呈负相关（P<0.05）。血清irisin水平升高是发生T2DM的保护因素（P<0.01）。结论 新诊断T2DM患者血清irisin水平下降，irisin与机体糖代谢、胰岛素抵抗以及炎症反应有关，可能对T2DM有一定的保护作用。

Relationship between irisin and newly diagnosed type 2 diabetes mellitus

Objective To explored the relationship between irisin and newly diagnosed type 2 diabetes mellitus (T2DM). Methods Forty newly diagnosed T2DM patients were collected as the T2DM group. During the same period, 40 healthy subjects in the physical examination center of the hospital were collected as the control (NC) group. Clinical indexes, metabolic indexes and serum concentrations of inflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and irisin were detected in the two groups. The differences of above indexes were analysed in the two groups. The correlation between irisin and the above indexes was analyzed. Logistic regression was used to analyze the relationship of irisin and newly diagnosed T2DM. Results Compared with the NC group, serum levels of cytokines IL-1β, IL-6, TNF-α and IFN-γ were significantly increased in the T2DM group (P<0.05), and the serum level of irisin was significantly decreased (P<0.05). The serum irisin was negatively correlated with FPG, 2 h PG, HbA1c, HOMA-IR, IL-1β and IFN-γ (P<0.05). The increased level of irisin was a protective factor for T2DM (P<0.01). Conclusion The serum level of irisin decreases in newly diagnosed T2DM patients. Irisin is closely related to glucose metabolism, insulin resistance and inflammation, which may have some protective effects on T2DM.