儿童卵巢无性细胞瘤一例并文献复习

儿童卵巢无性细胞瘤在临床较少见，结合病史及辅助检查综合考虑，手术在儿童卵巢无性细胞瘤中是首选方法。随着综合治疗模式的发展，需要考虑手术治疗后对于儿童生育力的保护及卵巢恶性肿瘤的管理。报告1例12岁儿童卵巢无性细胞瘤病例，患者因下腹胀痛首次就诊于延安大学附属医院儿科，发现盆腔包块后就诊于妇科，肛门指诊示盆腔偏右侧可触及约7.0 cm×6.0 cm包块，质中，边界尚清，活动可，相关肿瘤标志物（甲胎蛋白、糖类抗原125）略升高，剖腹探查行术中冰冻病理所示考虑左侧卵巢良性病变，右侧卵巢恶性病变，故行右侧附件切除术+左侧卵巢囊肿剥除术，术后给予辅助化疗同时给予戈舍瑞林去势保护卵巢功能治疗。现已随访11个月，患者月经规律，无特殊不适。通过回顾性分析儿童卵巢无性细胞瘤诊治过程及特点，以期提高临床医师对该病诊断、治疗及管理的认识。

Children Ovarian Dysgerminoma: A Case Report and Literature Review

Children ovarian dysgerminoma is uncommon in clinic practice. Combined with the history and the auxiliary examination, surgery in children ovarian dysgerminoma is the preferred approach. With the development and progress of the comprehensive treatment model, we need to consider the protection of children′s fertility and the management of ovarian malignant tumor after surgical treatment. Here we report the data of a 12-year-old child with ovarian dysgerminoma. The patient first seen in the department of pediatrics due to abdominal pain, and then went to the department of gynecology after finding pelvic mass. Anal examination indicated that a mass of about 7.0 cm×6.0 cm, quality medium, border clear and movable could be palpated on the right side of the pelvic cavity. The examination of relevant tumor markers showed that alpha-fetoprotein and carbohydrate antigen 125 increased slightly. Laparotomy and intraoperative freezing suggested that benign lesions were considered in the left ovary and malignant lesions in the right ovary, so right adnexectomy+excision of left ovarian cyst was performed. Adjuvant chemotherapy and goserelin castration were given to protect ovarian function after surgery. The patient has been followed up for 11 months and has regular menstruation without special discomfort. The diagnosis and treatment process and characteristics of ovarian dysgerminoma in children were reviewed in order to improve clinicians′ consideration of the diagnosis, treatment and management of this disease.