| 双硫仑的抗肿瘤作用及在泌尿系肿瘤中的研究进展 |
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| 引用本文： | 白吉彦1,张义木2,杨 栋1,何朝宏1. 双硫仑的抗肿瘤作用及在泌尿系肿瘤中的研究进展[J]. 现代肿瘤医学, 2023, 0(3): 556-560. DOI: 10.3969/j.issn.1672-4992.2023.03.033 |
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| 作者姓名： | 白吉彦1 张义木2 杨 栋1 何朝宏1 |
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| 作者单位： | 1.河南省肿瘤医院/郑州大学附属肿瘤医院，河南 郑州 450008；2.麻城市人民医院，湖北 麻城 438300 |
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| 基金项目： | 河南省医学科技攻关计划项目（编号:2018020506） |
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| 摘 要： | 双硫仑（disulfiram,DSF）为一种安全有效的戒酒药物。大量临床前研究表明，DSF具有明显的抗肿瘤作用，其抗肿瘤的分子机制包括乙醛脱氢酶（ALDH）抑制作用、抑制丝氨酸生物合成、诱导凋亡、抑制泛素-蛋白酶体蛋白核蛋白定位蛋白4(NPL4)和提高化疗药物的敏感性等。本文详细论述了双硫仑抗肿瘤活性成分、分子机理以及在泌尿系肿瘤中的研究进展及其应用前景。
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| 关 键 词： | 双硫仑 泌尿系肿瘤 抗肿瘤作用 抗肿瘤药物 |
Anti-tumor effect of disulfiram and its research progress in urologic tumors |
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| BAI Jiyan1,ZHANG Yimu2,YANG Dong1,HE Chaohong1. Anti-tumor effect of disulfiram and its research progress in urologic tumors[J]. Journal of Modern Oncology, 2023, 0(3): 556-560. DOI: 10.3969/j.issn.1672-4992.2023.03.033 |
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| Authors: | BAI Jiyan1 ZHANG Yimu2 YANG Dong1 HE Chaohong1 |
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| Affiliation: | 1.Henan Tumor Hospital,Henan Zhengzhou 450008,China;2.People's Hospital of Macheng City,Hubei Macheng 438300,China. |
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| Abstract: | Disulfiram (DSF) is a safe and effective drug for abstinence from alcohol.A number of preclinical studies have shown that DSF has obvious anti-tumor effects,and its molecular mechanisms include acetaldehyde dehydrogenase (ALDH) inhibition,inhibition of serine biosynthesis,induction of apoptosis,inhibition of ubiquitin-proteasome nucleoprotein locator protein 4 (NPL4),and enhancement of the sensitivity of chemotherapy drugs.In this paper,the anti-tumor active ingredients,molecular mechanism,research progress and application prospect of disulfiram in urologic tumors are discussed in detail. |
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| Keywords: | disulfiram urologic tumors anti-tumor effect anti-tumor drugs |
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