Neoadjuvant chemoradiotherapy for locally advanced rectal cancer: The debate continues |
| |
Authors: | Francesca De Felice Daniela Musio Luciano Izzo Vincenzo Tombolini |
| |
Affiliation: | Francesca De Felice, Daniela Musio, Vincenzo Tombolini, Department of Radiotherapy, Policlinico Umberto I “Sapienza” University of Rome, 00161 Rome, ItalyLuciano Izzo, Department of Surgery “Pietro Valdoni” Policlinico Umberto I “Sapienza” University of Rome, 00161 Rome, ItalyVincenzo Tombolini, Spencer-Lorillard Foundation, 00161 Rome, Italy |
| |
Abstract: | Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neo-adjuvant chemoradiotherapy, based on fluoropyrimidine (5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase III trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU in association with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9% (P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study. |
| |
Keywords: | Chemoradiotherapy Rectal cancer Locally advanced disease Neoadjuvant Debate |
|
| 点击此处可从《World journal of gastrointestinal oncology》浏览原始摘要信息 |
|