| 白细胞介素22结合蛋白在炎症相关性疾病中的研究进展 |
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| 引用本文： | 时静祥,曹际森,张金卷,王毅军. 白细胞介素22结合蛋白在炎症相关性疾病中的研究进展[J]. 天津医药, 2023, 51(1): 109-112. DOI: 10.11958/20220999 |
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| 作者姓名： | 时静祥 曹际森 张金卷 王毅军 |
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| 作者单位： | 天津市第三中心医院肝胆外科,天津市重症疾病体外生命支持重点实验室,天津市人工细胞工程技术研究中心,天津市肝胆疾病研究所（邮编300170 |
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| 基金项目： | 天津市医学重点学科（专科）建设项目(TJYXZDXK-034A) |
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| 摘 要： | 白细胞介素22结合蛋白（IL-22BP）是一种可溶性受体同系物,与白细胞介素受体（IL-22R）具有高度同源性,且其与白细胞介素（IL）-22结合的亲和力远高于IL-22R。IL-22BP可通过与IL-22结合抑制其表达来发挥维持机体免疫稳态的作用。该文对IL-22BP的产生、调节、分型以及在炎症相关性疾病中的研究进展加以综述,并探讨其作为治疗靶标的可行性。
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| 关 键 词： | 白细胞介素22 细胞因子 免疫 白细胞介素22结合蛋白 炎症相关性疾病 |
| 收稿时间： | 2022-07-07 |
| 修稿时间： | 2022-09-16 |
Research progress of interleukin 22 binding protein in inflammation related diseases |
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| SHI Jingxiang,CAO Jisen,ZHANG Jinjuan,WANG Yijun. Research progress of interleukin 22 binding protein in inflammation related diseases[J]. Tianjin Medical Journal, 2023, 51(1): 109-112. DOI: 10.11958/20220999 |
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| Authors: | SHI Jingxiang CAO Jisen ZHANG Jinjuan WANG Yijun |
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| Affiliation: | Department of Hepatobiliary Surgery, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Third Central Hospital of Tianjin, Tianjin 300170, China |
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| Abstract: | Interleukin 22 binding protein (IL-22BP) is a soluble receptor homolog that binds to interleukin 22 (IL-22) with greater affinity than the membrane spanning receptor. IL-22BP can play a role in maintaining immune homeostasis by inhibiting its expression and combining with IL-22. This review will focus on the production, regulation, typing of IL-22BP and its research progress in inflammatory related diseases, and explore the feasibility of it as a therapeutic target. |
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| Keywords: | interleukin 22 cytokine immunity interleukin 22 binding protein inflammation related diseases |
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