中国人群中血清TK1对原发性肝癌诊断价值的meta分析题录

目的通过meta分析研究中国人群中血清胸苷激酶1(TK1)对原发性肝癌的诊断价值。方法通过计算机检索数据库中有关中国人群中血清TK1在原发性肝癌诊断方面的相关文献, 对文献进行质量评价, 通过Stata 17.0对研究结果进行综合评价。文献检索时间从建库至2022年8月31日。结果共纳入22篇文献, meta分析结果显示TK1对原发性肝癌诊断的灵敏度(SE)=0.73(95%CI 0.67～0.78, P<0.05)、特异度(SP)=0.89(95%CI 0.85～0.92, P<0.05)、阳性似然比(PLR)=6.47(95%CI 4.76～8.80, P<0.05)、阴性似然比(NLR)=0.31(95%CI 0.25～0.37, P<0.05)、诊断比值比(DOR)=21.22(95%CI 13.42～33.55, P<0.05)、综合受试者工作特征曲线下面积(SROC-AUC)=0.88(95%CI 0.85～0.91, P<0.05)。TK1、甲胎蛋白(AFP)、Dickkopf-1(DKK1)联合诊断原发性肝癌的SE=0.88(95%C...

Diagnostic value of serum thymidine kinase 1 in Chinese population with primary liver cancer: a meta-analysis

Objective　To evaluate the diagnostic value of serum thymidine kinase 1 (TK1) in Chinese population with primary liver cancer (PLC) by a meta-analysis. Methods　Literatures about serum TK1 for diagnosing Chinese population with PLC were obtained through searching internet databases. The quality of included literatures was evaluated. Meta-analysis was employed by Stata 17.0. The deadline for literature publishing was August 31, 2022. Results　Totally 22 literatures were included. The results of meta-analysis showed that the sensitivity (SE) and specificity (SP) of TK1 for the diagnosis of PLC were 0.73 (95%CI 0.67-0.78, P<0.05) and 0.89 (95%CI 0.85-0.92, P<0.05), the positive likelihood ratio (PLR) was 6.47 (95%CI 4.76-8.80, P<0.05), the negative likelihood ratio (NLR) was 0.31 (95%CI 0.25-0.37, P<0.05), the diagnostic odds ratio (DOR) was 21.22 (95%CI 13.42-33.55, P<0.05), and the area under the summary receiver operating characteristic curve (SROC-AUC) was 0.88 (95%CI 0.85-0.91, P<0.05). The SE of the combination of TK1, alpha-fetoprotein (AFP), and Dickkopf-1 (DKK1) in the diagnosis of PLC was 0.88 (95%CI 0.85-0.90, P<0.05), the SP was 0.91 (95%CI 0.89-0.93, P<0.05), the PLR was 9.89 (95%CI 6.72-14.57, P<0.05), the NLR was 0.11 (95%CI 0.05-0.23, P<0.05), the DOR was 94.52 (95%CI 35.02-255.09, P<0.05), and the AUC was 0.97 (95%CI 0.63-0.99, P<0.05). The Youden index of combined diagnosis was 0.79, which was higher than 0.66 of TK1 alone. Conclusions　The SE of serum TK1 alone as a diagnostic index of PLC in Chinese population is fair, with a high SP, so it has a certain diagnostic value. The diagnostic value of TK1 combined with AFP and DKK1 is higher.