儿童肥胖与青春发动时相关联性研究进展

随着儿童超重肥胖率的不断升高，超重肥胖对青春发动时相的影响受到学者关注。为了解儿童肥胖与青春发动时相提前之间的相关性，研究就儿童肥胖与青春发动时相的关联及其机制进行综述，发现两者之间的关联与营养和代谢信号对下丘脑-垂体-性腺轴(HPG轴)功能的调节有关。女童肥胖与青春发动时相提前呈正相关，男童肥胖与青春发动时相关联的研究结论不尽相同。男童超重与青春发动时相提前相关；男童肥胖既可导致青春发动时相提前，也可导致其推迟，尚需进一步的研究揭示其中的规律。

Research progress on the association between childhood obesity and pubertal timing

With the increasing prevalence of overweight and obesity in children, the influence of overweight and obesity on pubertal timing has attracted the attention of scholars. This paper reviewed the correlation and mechanism between childhood obesity and pubertal timing, especially for earlier pubertal timing, and found that the regulation of hypothalamic-pituitary-gonadal axis function by nutrition and metabolic signals might under lie those associations. Obesity in girls was positively correlated with early pubertal timing, while the conclusions in boys were inconsistent. Overweight in boys was related to early pubertal timing, obesity in boys could lead to both earlier and later onset of puberty, which warrents further investigation.