肿瘤相关巨噬细胞在肺癌中的作用及研究进展

肿瘤相关巨噬细胞（TAMs）是肿瘤微环境中重要的炎性细胞。在各种不同刺激因子的作用下，TAMs可分化为经典活化型（M1）和交替活化型（M2）。M1-TAMs具有抑制恶性肿瘤活性的作用，M2-TAMs具有促进恶性肿瘤发展的作用。研究表明，肿瘤组织中的TAMs主要为M2型，可分泌多种趋化因子和细胞因子，从而促进肿瘤的增殖、侵袭转移、血管生成和耐药，并降低机体对肿瘤的免疫作用。本文将对TAMs的表型及其在肺癌中作用机制的新进展进行综述。

The role and research progress of tumor-associated macrophages in lung cancer

Tumor-associated macrophages (TAMs) are important inflammatory cells in the tumor microenvironment.Under the action of various stimuli,TAMs can be divided into classical activation (M1) and alternating activation (M2) types.M1-TAMs has the effect of inhibiting the malignant tumor activity,and M2-TAMs has the effect of promoting the development of the malignant tumor.It is shown that TAMs in tumor tissues are mainly M2 type and can secrete a variety of chemokines and cytokines to promote tumor proliferation,invasion and metastasis,angiogenesis and drug resistance,then reduce the immune effect of the body on the tumor.This review presents the phenotype of TAMs and new advances in its mechanism of action in lung cancer.