睡眠时长与非酒精性脂肪性肝病的关联

目的  基于2008－2018年北京市城区年龄≥18岁人群的体检资料，探究睡眠时长与非酒精性脂肪性肝病(non-alcoholic fatty liver disease，NAFLD)之间的关联。方法  利用北京美兆体检中心2008－2018年体检资料，采取横断面调查研究，采用多变量logistic回归分析模型探究睡眠时长与NAFLD患病之间的关联，并进一步分析不同亚人群中睡眠时长与NAFLD的关联。结果  共纳入77 697名体检对象，年龄为(40.7±11.7)岁，短睡眠时长(< 6 h)与长睡眠时长(≥8 h)分别占12.7%与7.0%，NAFLD的超声检出率为37.6%。调整潜在混杂因素后，短睡眠时长和长睡眠时长与正常睡眠时长的体检对象相比患有NAFLD的OR值分别为1.08(95% CI: 1.03~1.14，P=0.003)和0.88(95% CI: 0.82~0.95，P < 0.001)，且短睡眠时长与NAFLD的关联在男性(P_交互 < 0.05)及18~ < 30岁、30~ < 40岁的人群中(P_交互 < 0.001)更为显著；进一步调整BMI后，发现睡眠时长与NAFLD的关联无统计学意义(P > 0.05)。结论  睡眠时长与NAFLD风险有关，尤其在男性和年轻人中；BMI在睡眠时长与NAFLD的关系中起重要作用。

The association of sleep duration with non-alcoholic fatty liver disease

  Objective  To explore the association of sleep duration with non-alcoholic fatty liver disease (NAFLD) among a health checkup population aged 18 years or older in urban District of Beijing from 2008 to 2018.  Methods  A cross-sectional study was designed based on the health checkup data from 2008 to 2018 at Beijing MJ Health Screening Center. Multinomial logistic regression was used to explore the association of sleep duration with NAFLD, and further to assess the associations across different subgroups according to related covariates.  Results  Among 77 697 participants, the average age was (40.7±11.7) years. Of 12.7% reported a sleep duration of fewer than six hours, and 7.0% reported eight hours and more, respectively. The detection rate of NAFLD by ultrasound scan was 37.6%. After adjusting for the potential confounders, the odds ratio (95% CI) for NAFLD for short sleep duration and long sleep duration compared to the reference(normal sleep duration) were 1.08 (95% CI: 1.03-1.14, P=0.003) and 0.88 (95% CI: 0.82-0.95, P < 0.001), respectively. The association of short sleep duration with NAFLD was more substantial in males (P_interaction < 0.05) and individuals aged 18 to 29 and 30 to 39 years old (P_interaction < 0.001). However, the association was no longer significant (P > 0.05) when further adjusting BMI.  Conclusions  Sleep duration is associated with the risk of NAFLD, especially in males and young adults. Meanwhile, BMI played a vital role in the association between sleep duration and NAFLD.