运脾补血方辅助治疗缺铁性贫血患儿的临床效果分析

  目的  探讨运脾补血方辅助治疗缺铁性贫血患儿的近远期疗效及对铁代谢指标的影响。  方法  选取2019年9月—2020年6月嘉兴市中医医院收治的80例脾胃虚弱证营养性缺铁性贫血患儿，按随机数字表法分为对照组(40例)和观察组(40例)。对照组给予维生素C、右旋糖酐铁口服液治疗，在此基础上观察组加用运脾补血方。比较2组近远期疗效、不良反应、铁代谢及实验室指标水平。  结果  观察组临床总有效率为92.50%，明显高于对照组的75.00%(χ2=4.501，P < 0.05)；治疗后，观察组平均红细胞血红蛋白浓度、平均红细胞体积、血红蛋白、血清铁、转铁蛋白饱和度(328.45±32.84)g/L、(85.74±9.20)fL、(130.88±15.66)g/L、(16.65±3.12)μmol/L、(35.74±6.20)%]明显高于对照组(304.74±30.22)g/L、(75.33±8.82)fL、(118.30±17.26)μmol/L、(13.84±3.05)分、(30.55±6.84)%]，均P < 0.05；治疗后6个月，观察组复发率为7.50%，明显低于对照组的27.50%(χ2=5.541，P < 0.05)；观察组不良反应发生率(17.50%)与对照组(12.50%)相比差异无统计学意义(χ2=0.392，P>0.05)。  结论  运脾补血方辅助治疗缺铁性贫血患儿效果显著，能够有效调节机体血细胞及铁代谢情况，且安全性较好。 

Clinical effect of Yunpi Buxue Decoction in the treatment of children with iron deficiency anaemia

  Objective  This study aims to investigate the short-term and long-term curative effect of Yunpi Buxue Decoction in the treatment of children with iron deficiency anaemia and its influence on iron metabolism indexes to provide reference for their clinical treatment.  Methods  Eighty children with nutritional iron deficiency anaemia of spleen-stomach weakness syndrome who were admitted to Jiaxing Hospital of Traditional Chinese Medicine from September 2019 to June 2020 were selected and divided into the control group (n=40) and observation group (n=40) using the random number table method. The control group was treated with vitamin C combined with iron dextran oral liquid, and the observation group was treated with Yunpi Buxue Decoction based on the control group. The short-term and long-term efficacy, adverse reactions, iron metabolism indexes and laboratory index levels were compared between the 2 groups of children.  Results  The total clinical effective rate of the observation group (92.50%) was apparently higher in comparison with that of the control group (75.00%, χ2=4.501, P < 0.05). After treatment, the mean corpuscular haemoglobin concentration, mean corpuscular volume, haemoglobin, serum iron and transferrin saturation in the observation group (328.45±32.84) g/L, (85.74±9.20) fL, (130.88±15.66) g/L, (16.65±3.12) μmol/L, and (35.74±6.20) %] were apparently higher compared with those in the control group (304.74±30.22) g/L, (75.33±8.82) fL, (118.30±17.26) g/L, (13.84±3.05) μmol/L, and (30.55±6.84) %], all P < 0.05. Six months after treatment, the recurrence rate of the observation group (7.50%) was significantly lower in comparison with that of the control group (27.50%; χ2=5.541, P < 0.05). The incidence of adverse reactions in the observation group (17.50%) was not statistically significant compared with that in the control group (12.50%; χ2=0.392, P>0.05).  Conclusion  Yunpi Buxue Decoction combined with vitamin C and iron dextran oral liquid has a significant short-term and long-term curative effect on children with iron deficiency anaemia, which can effectively regulate the body' s blood cells and iron metabolism, and it has a better safety.