液体活检在神经胶质母细胞瘤诊断中的应用进展

胶质母细胞瘤（glioblastoma，GBM）是侵袭性极高、预后极差的中枢神经系统肿瘤。目前对于GBM的诊断主要依靠于影像学和组织活检。精准医学时代，液体活检这种相对无创的新兴检测手段已在诸多实体瘤中取得了显著的进展。与传统检测技术相比，液体活检弥补了传统组织活检有创和无法反复取样的局限。本文将针对液体活检循环肿瘤标志物如循环肿瘤DNA、microRNA、循环肿瘤细胞和外泌体在GBM 中的应用进展进行综述。

Progress in the application of liquid biopsy in the diagnosis of glioblastoma

Glioblastoma(GBM) is a central nervous system tumor with extremely aggressive and poor prognosis.At present,the diagnosis of GBM mainly relies on imaging and tissue biopsy.In the era of precision medicine,liquid biopsy,a relatively non-invasive new detection method,has made significant progress in many solid tumors.Compared with traditional laboratory technology,liquid biopsy makes up for the limitations of traditional tissue biopsy that are invasive and cannot be sampled repeatedly.This article will review the application progress of circulating tumor markers such as circulating tumor DNA,microRNA,circulating tumor cells and exosomes in GBM for liquid biopsy.