外泌体lncRNAs在结直肠癌中西医研究中的现状及思考

外泌体lncRNAs在结直肠癌发生发展中发挥着重要作用, 可通过诱导免疫逃逸、驱动上皮间充质转化、增加化疗及靶向治疗抗性、促进血管新生等影响结直肠癌的进程。古今医家认为结直肠癌基本病机为本虚标实, 本虚为正气亏虚, 标实为痰、湿、热、毒、瘀等病理因素交互为患, 外泌体lncRNAs通过多种途径影响结直肠癌的发生发展, 与中医学对结直肠癌“正虚邪实”病机的认识高度契合。通过梳理近年来外泌体lncRNAs在结直肠癌发生发展中的作用机制及中医药干预研究, 为未来中西医结合防治结直肠癌发生发展研究提供思路。 

Research Status and Thinking of Exosomal lncRNAs Affecting the Occurrence and Development of Colorectal Cancer with Integrated Traditional Chinese and Western Medicine

Exosomal lncRNAs play an important role in the occurrence and development of colorectal cancer, and can affect the process of colorectal cancer by inducing immune escape, driving epithelial-mesenchymal transition, increasing resistance to chemotherapy and targeted therapy, and promoting angiogenesis. Ancient and modern doctors believe that the basic pathogenesis of colorectal cancer is based on the deficiency of the standard of the real, the original deficiency is the deficiency of righteous qi, and the standard of the real is caused by the interaction of pathological factors such as phlegm, dampness, heat, toxin, and blood stasis. The occurrence and development of rectal cancer are highly consistent with the understanding of the pathogenesis of colorectal cancer in traditional Chinese medicine. This article combs the mechanism of exosomal lncRNAs in the occurrence and development of colorectal cancer in recent years and the research of traditional Chinese medicine intervention, and provides ideas for future research on the prevention and treatment of colorectal cancer with integrated traditional Chinese and western medicine.