An early effect of acute plasma volume expansion in humans on serum erythropoietin concentration |
| |
Authors: | Zbigniew Szyguła Johan Smitz Johan Roeykens Kenny De Meirleir Tom Klausen |
| |
Affiliation: | (1) Department of Sports Medicine, Academy of Physical Education, P.O. Box 62 (AWF), PL-31-571 Krakow 49, Poland;(2) Radioimmunoassay Laboratory, Free University of Brussels (VUB), Brussels, Belgium;(3) National Fund for Scientific Research, Brussels, Belgium;(4) Department of Sports Medicine and Human Physiology, Free University of Brussels (VUB), Brussels, Belgium;(5) Department of Rheumatology 232, Hvidovre Hospital, Hvidovre, Denmark |
| |
Abstract: | The effect of acute plasma volume change in humans on serum erythropoietin [EPO]s, plasma active renin [REN] and plasma aldosterone [ALDO] concentrations was examined. Plasma volume (PV) expansion was induced by intravenous infusion of 150 ml (30g) of plasma albumin and 500 ml of physiological saline. The [EPO]s decreased by 14.3% (corrected values for PV expansion) and remained decreased for 5 h. The [REN] was decreased by more than 25% during the day of the experiment and [ALDO] by more than 60%. Only a weak positive correlation was found between [EPO]s and [REN] (r = 0.35;P < 0.05) but a lack of correlation between changes in PV and [EPO]s as well as between [EPO]s and [ALDO] was seen. We postulated that in healthy men an acute PV expansion by 10% to 17.5% would not appear to promote stimulation of EPO synthesis for at least 11 h. Since a weak positive correlation was observed between [EPO]s and [REN] and a lack of correlation between [EPO]s and [ALDO], it would seem that there is no direct link between [REN] and [ALDO] and erythropoietin synthesis in healthy subjects.A preliminary report on the topic was presented at the 33rd German National Congress on Sportsmedicine, Padeborn, Germany |
| |
Keywords: | Erythropoietin Plasma volume Erythropoietin synthesis Aldosterone Plasma active renin |
本文献已被 SpringerLink 等数据库收录! |
|