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A significant imbalance in mitosis versus apoptosis accelerates the growth rate of sessile serrated adenoma/polyps |
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| Authors: | Akira Endo Hirotaka Koizumi Makiko Takahashi Tomohiro Tamura Shinobu Tatsunami Yoshiyuki Watanabe Masayuki Takagi |
| Affiliation: | 1. Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan 2. Unit of Medical Statistics, Faculty of Education and Culture, St. Marianna University School of Medicine, Kawasaki, Japan 3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan |
| Abstract: | Sessile serrated adenoma/polyps (SSA/Ps) of the colon are thought to be precursors of sporadic carcinomas. Although it is suggested that SSA/P may grow rapidly from the early stage, its cell kinetics remains obscure. To solve this problem, we analyzed the mitotic and apoptotic activity of normal crypts, microvesicular hyperplastic polyps (MVHPs), and tubular adenomas (TAs), using phospho-histone H3 and cleaved caspase 3 immunohistochemistry. The mitotic index for SSA/Ps (mean, 5.63) and TAs (6.98) was significantly higher than those for normal crypts (2.72) and MVHPs (2.86). Of all tested lesions, the apoptotic index was lowest for SSA/Ps (0.96; normal, 2.71; MVHPs, 2.62; TAs, 6.01) with statistically significant differences. The net growth ratio was close to 1.0 in normal crypts (1.07) while remaining low in MVHPs (1.06) and TAs (1.38), but was markedly elevated in SSA/Ps (7.32, P? |
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