| 三种基质金属蛋白酶在鼻息肉组织中的表达 |
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| 引用本文： | 张欣欣,郭永清,董震. 三种基质金属蛋白酶在鼻息肉组织中的表达[J]. 中华耳鼻咽喉头颈外科杂志, 1999, 34(6): 0 |
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| 作者姓名： | 张欣欣 郭永清 董震 |
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| 作者单位： | 长春白求恩医科大学第三临床学院耳鼻咽喉头颈外科 |
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| 摘 要： | 目的 探讨三种基质金属蛋白酶 (matrixmetalloproteinases,MMPs)与鼻息肉发病的关系。方法 采用免疫组化法对MMPs成员中MMP2、MMP9及MMP3在 3 2例鼻息肉组织中的表达进行研究。结果 正常鼻粘膜未见有三者的表达 ,鼻息肉组织中MMPs阳性细胞主要位于基底膜附近的细胞。上皮细胞、血液细胞及浸润的炎细胞表达MMP9;成纤维细胞、浸润的炎细胞和上皮细胞表达MMP2 ;少部分上皮细胞和浸润的炎细胞表达MMP3。与正常鼻粘膜相比 ,鼻息肉组织中三者的阳性细胞过度表达 ,三者的阳性细胞表达数比较 ,MMP9明显高于MMP2和MMP3 (P <0 0 1)。结论 MMP2、MMP9及MMP3在鼻息肉组织中过度表达 ,它们可破坏基底膜导致鼻粘膜病理性改变 ,在鼻息肉的发生发展中起到了重要的作用 ,MMP9似乎起到了更重要的作用
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| 关 键 词： | 鼻息肉 金属蛋白酶类 鼻粘膜 |
The significance of matrix metalloproteinases expression in nasal polyps |
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| ZHANG Xinxin,GUO Yongqing,DONG Zhen,et al Third Clinical College of Norman Bethune University of Medical Sciences,Changchun. The significance of matrix metalloproteinases expression in nasal polyps[J]. Chinese journal of otorhinolaryngology head and neck surgery, 1999, 34(6): 0 |
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| Authors: | ZHANG Xinxin GUO Yongqing DONG Zhen et al Third Clinical College of Norman Bethune University of Medical Sciences Changchun |
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| Affiliation: | ZHANG Xinxin,GUO Yongqing,DONG Zhen,et al Third Clinical College of Norman Bethune University of Medical Sciences,Changchun 130031 |
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| Abstract: | Objective To explore the role of matrix metalloproteinases(MMPs) in nasal polyp formation Methods The expression of MMP9,MMP2 and MMP3 was studied in 32 nasal polyps by immunohistochemical method Results MMPs could not be detected in all samples of normal mucosa In nasal polyp tissue, MMP9 was observed epithelial in cells , inflammatory cell and blood cells, MMP2 was detected in fibroblasts, epithelial cells and inflammatory cells, and MMP3 was detected in inflammatory cells and epithelial cells Compare to normal mucosa, MMP9, MMP2 and MMP3 was over expressed in their positive cells of polyp The expression of MMP9 was higher than that of MMP2 and MMP3 in nasal polyp tissue ( P <0 01) Conclusion MMP9, MMP2 and MMP3 were strongly correlated with nasal polyp formation They cause pathological changes in nasal mucosa and MMP9 may play the most important role among them |
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| Keywords: | Nasal polyps Metalloproteinases Nasalmucosa |
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