| 氯化饮用水的煮沸效果：遗传毒性和Cyt P—450活性及其诱导化学发光的研究 |
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| 引用本文： | 张荣泉.氯化饮用水的煮沸效果：遗传毒性和Cyt P—450活性及其诱导化学发光的研究[J].癌变．畸变．突变,1992,4(5):30-33. |
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| 作者姓名： | 张荣泉 |
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| 作者单位： | 上海市防疫站 上海 |
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| 摘 要： | 自来水(氯化消毒饮用水)浓缩液对大鼠肝细胞色素P-450(Cyt P-450)含量和苯胺羟化酶具有明显的抑制作用,对肝微粒体代谢相关的化学发光效应具有诱导作用。但水煮沸后,其致突变性降低约一倍,且对前者的抑制和对后者的诱导作用都显著减弱。提示煮沸能有效降低自来水的遗传毒性,减轻对Cyt P-450的抑制和对细胞过氧化态的诱导,缓解对突变基因表达的促进作用。
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| 关 键 词： | 自来水 化学发光 致突变 |
EFFECTS OF BOILIONG ON THE GENOTOXICITY, CYTOCHROME P450 AND MICROSOMAL CHEMILUMINESCENCE OF TAP WATER |
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| Zhang Rongqian,Shanghai Hygiene and Anti-epidemic centre Shanghai.EFFECTS OF BOILIONG ON THE GENOTOXICITY, CYTOCHROME P450 AND MICROSOMAL CHEMILUMINESCENCE OF TAP WATER[J].Carcinogenesis,Teratogenesis and Mutagenesis,1992,4(5):30-33. |
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| Authors: | Zhang Rongqian Shanghai Hygiene and Anti-epidemic centre Shanghai |
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| Institution: | Zhang Rongqian
Shanghai Hygiene and Anti-epidemic centre Shanghai 200335 |
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| Abstract: | Treatment of rats with concentrated tap water caused both suppression of some forms of the hepatic cytochrome P450 dependent monoxygenase and induction of chemiluminescence (CL) arising from microsomes. But both the suppression of monoxygenase and the induction of microsomal CLs caused by the boiled water were less than that by raw water. These effects seemed to be associated with the reduced genotoxicity of water by boiling. It is suggested that the boiling of tap water might reduce in vivo the induction of cellular peroxidant states. |
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| Keywords: | tap water genotoxicity cytochrome P-450 free radicals chemiluminescence |
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