| OGG1 mRNA在鼻咽癌组织中的表达及其意义 |
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| 引用本文： | 夏春波,蒋常文,刘源劼,周思,刘静,张晓红.OGG1 mRNA在鼻咽癌组织中的表达及其意义[J].实用医学杂志,2010,26(5). |
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| 作者姓名： | 夏春波 蒋常文 刘源劼 周思 刘静 张晓红 |
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| 作者单位： | 桂林医学院人体解剖学教研室,541004 |
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| 摘 要： | 目的:探讨OGG1 mRNA表达在鼻咽癌发生发展过程中的作用,以及OGG1 mRNA表达与鼻咽癌患者的癌细胞分化程度和淋巴转移之间的关系.方法:通过HE染色从组织病理学上确定鼻咽组织的良、恶性以及恶性组织的分级.应用RT-PCR法检测45例鼻咽癌组织和17例正常鼻咽组织中OGG1 mRNA的表达情况.结果:鼻咽癌组织OGG1 mRNA表达的阳性率为57.78%,明显低于正常鼻咽组织(88.24%),两者比较差异有显著性(P<0.05).OGG1 mRNA表达随分化程度降低而降低(P<0.01),有淋巴转移的患者低于无淋巴转移的患者(P<0.05).结论:OGG1 mRNA在鼻咽癌组织中表达水平明显降低,提示它与鼻咽癌发生发展有关;鼻咽癌组织OGG1 mRNA表达水平的差异,对鼻咽癌的病理诊断及其分级有参考价值.
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| 关 键 词： | 鼻咽肿瘤 OGG1基因 |
Expression of OGG1 mRNA in nasopharyngeal carcinoma and its significance |
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| XIA Chun-bo,JIANG Chang-wen,LIU Yuan-jie,ZHOU Si,LIU Jing,ZHANG Xiao-hong.Expression of OGG1 mRNA in nasopharyngeal carcinoma and its significance[J].The Journal of Practical Medicine,2010,26(5). |
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| Authors: | XIA Chun-bo JIANG Chang-wen LIU Yuan-jie ZHOU Si LIU Jing ZHANG Xiao-hong |
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| Institution: | XIA Chun-bo,JIANG Chang-wen,LIU Yuan-jie,ZHOU Si,LIU Jing,ZHANG Xiao-hong.Department of Anatomy,Guilin Medical University,Guilin 541004,China |
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| Abstract: | Objective To explore the role of OGG1 mRNA expression in the genesis and development of nasopharyngeal carcinoma and the association of this expression with cancer cell differentiation and lymphatic metastasis.Method The nasopharyngeal tissues were histopathologically identified as benign or malignant using HE staining and then the malignancy was graded.OGG1 mRNA expressions were detected by RT-PCR in the malignant tissues from 45 patients and the normal nasopharyngeal tissue from 17 subjects.Results The ra... |
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| Keywords: | RT-PCR |
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