拉坦前列素及噻吗心安治疗开角型青光眼的疗效观察及安全性评估

目的 研究拉坦前列素及噻吗心安治疗开角型青光眼的疗效及安全性.方法 将120例开角型青光眼患者纳入研究对象,随机分为给予拉坦前列素联合噻吗心安治疗的观察组和单独给予噻吗心安治疗的对照组,检测视野缺损情况、视网膜神经纤维层厚度并观察不良反应例数.结果 （1）观察组患者的上方视野（4.9±0.8） dB、下方视野（5.1±0.9）dB、颞侧视野（7.2±1.3）dB、鼻侧视野缺损（6.9± 1.1） dB均明显低于对照组（P＜0.05）;（2）观察组患者的上方视野（92.3±13.2）μm、下方视野（90.8± 12.1） μm、颞侧视野（74.2±10.3）μm、鼻侧视野RNFL厚度（70.8±12.3）μm均明显高于对照组（P＜0.05）;（3）两组患者发生不良反应例数比较差异无统计学意义（P＞ 0.05）.结论 拉坦前列素及噻吗心安治疗开角型青光眼有助于改善视野缺损和视网膜神经纤维层厚度,且保证相当的安全性,具有积极的临床价值.

Efficacy observation and safety evaluation of latanoprost and timolol maleate in treating open angle glaucoma

Objective To study the efficacy and safetv of latanoprost and timolol maleate in treating open angle glaucoma.Methods Open angle glaucoma patients were enrolled and randomly divided into observation group （given latanoprost and timolol maleate） and control group （given timolol maleate）.Then RNFL thickness,visual field defect degree were detected and adverse reaction was observed.Results ① Field defect in above view field,lower visual field,visual field,nasal visual field of observation group were lower than those of control group; ② RNFL thickness in above view field,lower visual field,visual field,nasal visual field of observation group were higher than those of control group; ③There were no statistical significant difference found in incidence of adverse reaction cases between two groups.Conclusion Latanoprost and timolol maleate have positive clinical value for it can improve RNFL thickness,visual field defect and achieve equal safety.