| 胃癌患者EB病毒感染与Cyclin D1基因表达的相关性 |
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| 引用本文： | 李淑英,张科,周天戟. 胃癌患者EB病毒感染与Cyclin D1基因表达的相关性[J]. 医学争鸣, 2006, 27(21): 1932-1933 |
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| 作者姓名： | 李淑英 张科 周天戟 |
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| 作者单位： | 华北煤炭医学院,生物科学系微生物学科,河北,唐山,063000;华北煤炭医学院,成人教育学院函授科,河北,唐山,063000 |
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| 基金项目： | 教育部留学回国人员科研启动基金 |
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| 摘 要： | 目的:研究胃癌患者癌组织中EB病毒(EBV)感染与Cyclin D1表达的关系. 方法:原位杂交法检测胃癌患者石蜡标本中EBV编码的小RNA(EBER1);免疫组化法检测EBV阳性胃癌[EBV( )] 及EBV阴性胃癌[EBV(-)]标本细胞周期蛋白Cyclin D1的表达状况. 结果:胃癌患者癌组织标本217例中23例EBER1( ); EBV( )组Cyclin D1蛋白表达显著高于EBV(-)组(P＜0.01). 结论:EBV感染可能上调Cyclin D1表达.
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| 关 键 词： | 疱疹病毒4型 人 胃肿瘤 癌基因蛋白质类 |
| 文章编号： | 1000-2790(2006)21-1932-02 |
| 修稿时间： | 2005-12-19 |
Relativity between EBV infection and expression of Cyclin D1 in gastric carcinoma patients |
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| LI Shu-Ying,ZHANG Ke,ZHOU Tian-Ji. Relativity between EBV infection and expression of Cyclin D1 in gastric carcinoma patients[J]. Negative, 2006, 27(21): 1932-1933 |
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| Authors: | LI Shu-Ying ZHANG Ke ZHOU Tian-Ji |
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| Abstract: | AIM:To investigate the relativity between the Epstein- Barr Virus (EBV) infection and the expression of Cyclin D1 in gastric carcinoma (GC) patients. METHODS: EBER_1 in 217 cases of GC was detected with in situ hybridization. Then, EBV positive and negative GC cases were selected for analysis of the expression of Cyclin D1 by immunohistochemistry. RESULTS: In 217 GC cases there were 23 cases with EBER_1 positive expression. The expression of Cyclin D1 was higher in the EBV positive GC than that in the EBV negative (P<0.01). CONCLUSION: EBV infection in GC may upregulate the expression of Cyclin D1. |
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| Keywords: | herpesvirus 4 human stomach neoplasm oncogene protein |
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