Half-Life of Alpha-Fetoprotein in Patients with a Teratoma, Endodermal Sinus Tumor, or Hepatoblastoma |
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Authors: | C M Walhof L Van Sonderen P A Voû te J F M Delemarre |
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Institution: |
a Werkgroep Kindertumoren, Emma Kinderziekenhuis and Antoni van Leeuwenhoekziekenhuis, Netherlands Cancer Institute, Amsterdam, The Netherlands |
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Abstract: | To evaluate the AFP-concentralion postoperatively and/or during chemotherapy treatment, a retrospective study was carried out on 14 patients with a teratoma, endodermal sinus tumor (EST), or hepatoblastoma. Eleven patients were operated. Eight of the 11 patients showed postoperatively a linear decline in their AFP concentration. The half-life was about 6 days. In the group of patients that underwent a noncomplete resection, both a linear and a nonlinear declining pattern was seen. The patients that underwent a complete resection showed only a linear decline in the AFP concentration. No relationship was found between the reduction pattern of the AFP and the development of recurrences. The development of a recurrence was accompanied by an increasing AFP concentration. |
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Keywords: | alpha-fetoprotein germ cell tumors hepatoblastomas |
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