序贯抗凝治疗短暂性脑缺血发作及进展性卒中58例临床观察

目的 探讨序贯抗凝在治疗缺血性脑血管病的临床效果。方法 收集58例患者，频繁发生的短暂性脑缺血发作（TIA）28例及进展性卒中30例，应用肝素抗凝等治疗后病情仍继续进展的，改用口服华法林抗凝，进行疗效评价。结果 痊愈24．1％；显效50％；好转17．3％，无效8．6％；用药前后神经功能缺损程度评分比较P〈0．01有非常显著性差异。结论 临床序贯抗凝治疗缺血性脑血管病，治愈、好转率高，后遗症少，是值得临床广泛应用的一种可行的治疗方法。

Clinical study of Sequently Anti-coagnlation Therapy of TIA and Progressive Stroke

Objective To study the clinical effect of sequent anti-coagnlation treatment of ischemic cerebral vascicular disease. Methods 28 frequent TIA and 30 progressive ischemic stroke patients were studyed.The patients with progressive stroke were given gener- al anti-coagnlation and other common therapy firstly.Those who got worse clinical symptoms and signs received uarfafin orally.The effects of before and after uarfarin therapy were compared.Results Of all the 58 patients,24.1% patients recovered completely,50% improved obviously,17.3% improved and 8.6% had no effects,before and after takeing medicines the score Comparison about neurological impair- ment degree has a highly signifient difference(P<0.01).Conclusions Comparing with general treatment,sequent anti-coagnlation therapy can give patients with ischemic cerebral vascicular disease a higher recovery rate and less sequels.Sequent anti-coagnlation thera- py may be widely used clinically.