| ~(14)C-杀灭菊酯在小鼠体内的吸收、分布和排出 |
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| 引用本文： | 龚梓初,林惠芬,张瑾岗,金锡鹏. ~(14)C-杀灭菊酯在小鼠体内的吸收、分布和排出[J]. 复旦学报(医学版), 1989, 0(4) |
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| 作者姓名： | 龚梓初 林惠芬 张瑾岗 金锡鹏 |
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| 作者单位： | 上海医科大学公共卫生学院劳动卫生学教研室，上海医科大学公共卫生学院劳动卫生学教研室，上海医科大学公共卫生学院劳动卫生学教研室，上海医科大学公共卫生学院劳动卫生学教研室 本教研室进修生 |
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| 摘 要： | 本文采用~(14)C-杀灭菊酯的放射性测量及整体放射自显影术,研究杀灭菊酯在小鼠体内的吸收、分布和排出规律。结果表明,给小鼠一次灌胃,~(14)C-杀灭菊酯经消化道吸收速率常数为1.68h~(-1);血药浓度达峰时间1.98 h;排出相半衰期为24.32h。杀灭菊酯主要分布于肝、肾、肺、皮肤和毛,给药后第5天在皮肤和毛发中仍能检出较高的~(14)C放射性。~(14)-C杀灭菊酯及其代谢物主要经尿排出,部分可贮存于小鼠皮肤和毛发中。
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| 关 键 词： | 杀灭菊酯 放射性同位素 放射自显影术 毒物动力学 |
STUDIES ON THE ABSORPTION DISTRIBUTION AND ELIMINATION OF ~(14)C-FENVALERATE IN MICE |
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| Gong Zichu,Lin Huifen,Zhang Jingang,Jin Xipeng. STUDIES ON THE ABSORPTION DISTRIBUTION AND ELIMINATION OF ~(14)C-FENVALERATE IN MICE[J]. Fudan University Journal of Medical Sciences, 1989, 0(4) |
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| Authors: | Gong Zichu Lin Huifen Zhang Jingang Jin Xipeng |
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| Abstract: | Using ~(14)C isotopio measurement and autoradiography, the absorption, distribu-bion and elimination of Fenvalerate were studied in mice. The results showed that after gastric intubation, the Ka, Tmax and T1/2/8 of 14G-Fenvalerate were 1.68h-1, 1.98 h and 24.32 h, respaotively, 14C-Fenvalerate wag distributed mainly in the liver, kideny, lung, skin and hair of the mouse. Higher concentration of 14C isotope were detected in the skin and hair 120 h af ber intubation. 14C-Fenvalerate and its metabolites can bj partially stored in the skin and fur of the mouse. They are principally eliminated through urine. |
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| Keywords: | Fenvalerate radioisotope autoradiography toxicokiuetics |
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