初诊2型糖尿病30例短期强化胰岛素治疗诱发“蜜月期”临床观察

目的:观察短期胰岛素强化治疗对伴有明显高血糖的初诊2型糖尿病患者的降糖效果和停药后情况。方法:对30例空腹血糖>11.1mmol/L的初诊T2DM患者进行短期胰岛素强化治疗,比较其治疗前后空腹血糖(FBD),糖化血红蛋白及停药后血糖的观察情况。结果:治疗1～3月后患者空腹及餐后血糖、HbA1c均达到良好控制,且停用胰岛素后有2/3病人不需服用任何药物。结论:对有明显高血糖的初诊2型糖尿病患者短期用胰岛素治疗,可快速控制血糖,且停药后可诱发较长时间(6～24月)的"蜜月期"。

Clinical observation of the induced "honeymoon" period in 30 cases of preliminarily diagnosed type 2 diabetes mellitus undergone insulin therapy

Objective：To observe the hypoglycemic effect of intensive short-term insulin therapy in preliminarily diagnosed type 2 diabetics（T2DM） with significant hyperglycemia and the outcome of drug withdrawal.Methods：Thirty newly diagnosed T2DM patients with fasting blood glucose （FBG）11.1mmol/L received intensive short-term insulin therapy.The biochemical indicators were determined with regard to FBG and glycosylated hemoglobin level before and after the medication as well as the level change after the drug withdrawal.Results：After 1 to 3 months of the medication,the patients were well managed in FBG and 2-hour postprandial HbA1c.Two-thirds of the patients were non-insulin dependent after the drug withdrawal.Conclusion：Intensive short-term insulin therapy can produce early effect on T2DM patients with marked hyperglycemia,and it may induce a longer so-called ＂honeymoon＂ period following drug discontinuance.