| 蒿甲醚对小鼠免疫功能的影响 |
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| 引用本文： | 张丹,林培英,潘竞锵,杨卫路. 蒿甲醚对小鼠免疫功能的影响[J]. 中国药理学通报, 1989, 0(1) |
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| 作者姓名： | 张丹 林培英 潘竞锵 杨卫路 |
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| 作者单位： | 广州市医药卫生研究所药物研究室(张丹，林培英，潘竞锵)，广州市医药卫生研究所药物研究室(杨卫路) |
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| 摘 要： | JCR鼠按200mg/kg·d~(-1)每天蒿甲醚灌胃2次,连续给药4～7d。实验结果可见:(1)蒿甲醚能引起小鼠腹腔巨噬细胞对鸡红细胞的吞噬率降低,但对巨噬细胞的吞噬指数无明显影响。(2)降低鸡红细胞致敏小鼠血清IgG含量。(3)促进鸡红细胞致敏小鼠的溶血素形成。(4)能使鸡红细胞致敏小鼠胸腺重量明显减轻。(5)对PHA诱导的小鼠外周血淋巴细胞转化无明显影响。
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| 关 键 词： | 蒿甲醚 吞噬功能 免疫球蛋白G 溶血素 淋巴细胞转化 |
EFFECTS OF ARTEMETHER ON IMMUNOLOGICAL FUNCTIONS IN MICE |
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| Zhang Dan,Lin Peiying,Pan Jingqiang Yang Wcilu. EFFECTS OF ARTEMETHER ON IMMUNOLOGICAL FUNCTIONS IN MICE[J]. Chinese Pharmacological Bulletin, 1989, 0(1) |
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| Authors: | Zhang Dan Lin Peiying Pan Jingqiang Yang Wcilu |
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| Abstract: | The effects of Artemether on immune responses were investigated in mice. After p.o. administration of Artemether 200 mg/kg·d-1 for 4-7 days, it was found that: ( 1 ) the percentage of phagocytosis in peritoneal macrophage was reduced, but the phagocytic index was not significantly affected; ( 2 ) the level of serum IgG was markedly lowered in the mice sensitized by cock red blood cell ( CRBC ); ( 3 ) the hemolysin-forming capacity of CRBC-sensitized mice was significantly enhanced; ( 4 ) the weight of thymus was markedly decreased in the mice sensitized with CRBC; ( 5 ) no significant effect in PHA-induced lymphocyte transformation was found. |
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| Keywords: | Artemether Phagocytic function IgG Hemolysin Lymphocyte transformation |
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