COX-2启动子区遗传变异与胃癌发病风险的关系

目的 COX-2的过度表达在肿瘤的发生发展中起重要作用,本文探讨COX-2启动子区单核苷酸多态与胃癌易感性的关系。方法以聚合酶链反应-限制性片段长度多态性对155例胃癌患者和237例正常对照进行基因分型,以logistic回归的比值比（OR）及其置信区间（CI）来评估风险度。结果 COX-2-1290AG及GG基因型与胃癌的发病风险无关,OR为1.24（95%CI=0.66-2.35）。而携带COX-2-1195GA或-1195AA基因型的个体胃癌发病风险显著增加,OR分别为1.91（95%CI=1.05-3.47）,2.71（95%CI=1.40-5.27）。单体型分析发现A_1290-A_1195单体型显著增加了胃癌的发病风险（OR=1.49,95%CI=1.10-2.01）。结论 COX-2启动子区-1195G→A遗传变异与胃癌发病风险相关。

Genetic polymorphisms in the promoter of Cyclooxygenase-2 and their association with the risk of gastric cancer

Objective:Overexpression of cyclooxygenase（COX）-2 has been implicated in the development of cancer.This study aimed to evaluate the relationship between genetic variants in COX-2 promoter and the susceptibility to gastric cancer（GC）.Methods:Two COX-2 polymorphisms（-1290A>G and-1195G>A） were genotyped in 155 GC patients and 237 controls.Odds ratios（ORs） and 95% confidence intervals（CIs） were calculated by logistic regression model.Results:The genotype-1290AG or GG did not show significant association with gastric cancer risk,and the OR was equal to 1.24（95% CI = 0.66-2.35）.For-1195G→A polymorphism,the ORs were 1.91（95% CI = 1.05-3.47） and 2.71（95%CI = 1.40-5.27） for-1195GA or-1195AA genotype carriers,respectively.Haplotype analysis showed that the A₁290-A₁195 haplotype was associated with increased risk for gastric cancer,compared with the A₁290-G₁195 haplotype（OR=1.49,95% CI=1.10-2.01）.Conclusion:Our results suggested that the COX-2 promoter-1195G→A polymorphisms were associated with increased risk of gastric cancer.