| P21和Cyclin D1mRNA在食管癌的表达及其意义 |
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| 引用本文： | 张洁,魏林郁.P21和Cyclin D1mRNA在食管癌的表达及其意义[J].医学信息,2008,21(6). |
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| 作者姓名： | 张洁 魏林郁 |
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| 作者单位： | [1]新乡医学院病理教研室,河南新乡453003 [2]新乡医学院生理教研室,河南新乡453003 |
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| 摘 要： | 目的探讨p21和Cyclin D1mRNA在食管癌中的表达及其临床意义。方法应用RT-PCR检测45例食管癌组织及其对应的正常组织中p21和Cyclin D1mRNA的表达水平。结果p21 mRNA在肿瘤组织的表达显著低于正常组织（P〈0．05），p21mRNA表达减弱与食管癌的临床分期、肿瘤的分化程度相关（P〈0．05）；Cyclin D1mRNA在肿瘤组织的表达显著高于正常组织（P〈0．05），Cyclin D1mRNA表达增强与食管癌的临床分期、肿瘤的分化程度相关（P〈0．05）；在食管癌组织中，p21 mRNA表达与Cyclin D1mRNA呈负相关（r=-0．757，P〈0．05）。结论p21 mRNA的表达下调、Cyclin D1mRNA参与食管癌的发生、发展。
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| 关 键 词： | p21 Cyclin D1 食管癌 |
Expressions of p21,Cyclin D1mRNA in esophageal carcinoma and its significance |
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| ZHANG Jiea,WEI Lin-yub.Expressions of p21,Cyclin D1mRNA in esophageal carcinoma and its significance[J].Medical Information,2008,21(6). |
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| Authors: | ZHANG Jiea WEI Lin-yub |
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| Institution: | ZHANG Jiea,WEI Lin-yub(a.Department of Physiology,b.Department of Pathology,Xinxiang Mdical University,Xinxiang 453003,Henan Province,China) |
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| Abstract: | Objective To investigate the expressions of p21,Cyclin D1mRNA in esophageal carcinoma and its clinical significance.Methods Expressions of p21,Cyclin D1mRNA were determined by RT-PCR in 45 esophageal tumor tissues and matched esophageal normal tissues.Results The expression of p21 mRNA in tumor tissues was lower than that in normal tissues significantly (P<0.05),and the low expression of p21mRNA correlated with differentiation degree and clinical stage of tumor cells (P<0.05);the expression of Cyclin D1 mRN... |
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| Keywords: | p21 Cyclin D1 esophageal carcinoma |
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