Differentiating moderate and severe depression using the Montgomery-Asberg depression rating scale (MADRS) |
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Authors: | Müller Matthias J Himmerich Hubertus Kienzle Barbara Szegedi Armin |
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Affiliation: | Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55131, Mainz, Germany. mjm@mail.psychiatrie.klinik.uni-mainz.de |
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Abstract: | BACKGROUND: MADRS cut-off scores for moderate and severe depression were estimated in relation to the Hamilton Depression Rating Scale (HAMD(17)) and the Clinical Global Impressions Scale (CGI). METHOD: HAMD(17), MADRS, and CGI ratings from patients with major depression (DSM-IV) were analyzed (N=85). Receiver operating characteristics (ROC) curves were applied. RESULTS: Mean age was 51.4+/-14.5 years, 69% were female. Mean MADRS scores were 23.4+/-13.2, HAMD(17), MADRS, and CGI scores were highly correlated (r>0.85; P<0.0001). Best separation between moderate and severe depression according to CGI criteria was achieved with a MADRS score of 31 (sensitivity 93.5%, specificity 83.3%). LIMITATIONS: Studies to validate severity gradations including DSM-IV or ICD-10 diagnostic severity categories are recommended. CONCLUSIONS: Empirically based MADRS cut-off scores to separate moderate from severe depression on the basis of HAMD(17) and CGI severity ratings in patients with major depression were yielded. |
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