补肾通络方对糖尿病周围神经病变氧化应激影响

目的:观察补肾通络方对糖尿病周围神经病变(DPN)氧化应激影响.方法:将48例DPN患者随机分为治疗组30例,对照组18例,两组均给予常规治疗+硫辛酸针,治疗组在对照组基础上配合补肾通络方治疗,疗程90 d.观察患者临床疗效及血糖、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(CHOL)、神经传导速度、丙二醛(MDA)、超氧化物歧化酶(SOD)的变化.结果:治疗后总有效率治疗组83.3％,对照组为66.7％,两组比较差异显著(P＜0.05).两组治疗后空腹血糖(FBG),HbA1c,TG,CHOL较治疗前显著下降(P＜0.05)；且治疗组TG,CHOL下降明显优于对照组(P＜0.05).治疗后两组运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)较治疗前明显提高(P＜0.01,P＜0.05)；治疗组提高明显优于对照组(P＜0.01).治疗后两组MDA较治疗前明显下降,SOD较治疗前明显提高(P ＜0.01,P＜0.05)；治疗组MDA下降、SOD提高明显优于对照组(P＜0.01).结论:在对照组治疗基础上配合补肾通络方治疗DPN可以提高临床疗效,改善血脂代谢,降低氧化应激反应,提高神经传导速度.

Influence of Bushen Tongluo Fang on Diabetic Peripheral Neuropathy Oxidative Stress

Objective:To observe the influence Bushen Tongluo fang on diabetic peripheral neuropathy (DPN) oxidative stress. Method: Fourty-eight DPN patients were randomly divided into 2 groups, 30 cases in treatment group and 18 cases in control group, two groups were given conventional treatment and lipoic acid for 90 days, in the same time the treatment group were given Bushen Tongluo fang. The clinical curative effect and changes of blood sugar,haemoglobin A1c (HbA1c),triglyceride (TG), total cholesterol(CHOL), nerve conduction velocity, malondialdehyde (MDA), superoxide dismutase (SOD) were observed. Result: After treatment, the total effective rate of treatment group was 83.3%, and the placebo group was 66.7%. Between the two groups, the difference was significant (P<0.05). The levels of fasting blood glucose(FBG), HbA1c, TG, CHOL in two groups were significant declined than before (P<0.05), and TG, CHOL declined was better in treatment group than control group (P<0.05). After treatment, motor nerve conduction velocity(MNCV), sensory nerve conduction velocity(SNCV) in two groups were obviously improved than before (P<0.01, P<0.05), and the improvement in treatment group was better than control group (P<0.01). After treatment, MDA was markedly reduced (P<0.01) and SOD obviously improved (P<0.01, P<0.05) in two groups, and the effect in treatment group was better than control group (P<0.01). Conclusion: Bushen Tongluo fang on the basis of conventional treatment and lipoic acid in the treatment of DPN patients can improve the clinical curative effect, improve lipid metabolism, reduce oxidative stress reaction and improve nerve conduction velocity.