心肾双补强心方对慢性心衰患者心功能、血浆BNP及相关指标的影响

目的:观察心肾双补强心方对40例慢性心衰患者的临床疗效及心功能、血浆脑钠肽(BNP)等相关指标的影响.方法:将40例慢性心衰患者双盲法随机分为两组.两组基础治疗相同,均给予低盐饮食,卧床休息,必要时吸氧并根据病情口服常规西药(ACEI、利尿剂、血管扩张剂、洋地黄制剂、β受体阻滞剂)等.治疗组在此基础上加用心肾双补强心方治疗,煎煮取汁150 mL,每日2次.8周为1疗程.观察记录患者治疗前后的症状、舌苔、脉象的变化及心脏超声检查指标,左室舒张末期内径(LVEDD)、收缩末期内径(LVESD)、射血分数(EF);BNP、血浆内皮素(ET)及一氧化氮(N0)含量的测定,并记录治疗前后安全性指标,如血压、心电图、肝肾功能、血流变、血、尿常规.详细记录用药过程中的不良反应.结果:加服心肾双补强心方慢性心衰患者的血浆ET,LVEDD,LVESD,NO均较服用前明显降低(P＜0.05),BNP水平显著降低(P＜0.01),射血分数EF明显上升(P＜0.01).结论:心肾双补强心方是治疗慢性心衰疗效可靠、服用安全的药物,无任何毒副作用,其对提高患者的生活质量,减少病死率有着及其重要的临床意义.

Effect of Xinshen Shuangbu Qiangxin Decoction on Plasma BNP and Related Index of Heart Function in Chronic Heart Failure Patients

Objective:To observe the effect of heart and kidney-reinforcing formula related indicators and the plasma brain natriuretic peptide (BNP) of in chronic heart failure patients. Method: Forty cases with chronic heart failure patients based on double blind method were randomly divided into two groups. The two groups were given the same basic treatment, including low salt diet, bed rest, when necessary, the condition of oral inhalation and routine western medicine (ACEI, diuretics, vasodilators, digitalis, beta blockers) were carried out. The treatment group was given the heart-kidney treatment of cardiac double compensation, boiling juice 150 mL, 2 times a day,course of treatment lasted8 weeks.The following indexes were observed and record ed before and after treatment,symptoms, tongue, pulse and cardiac ultrasound index, left ventricular end diastolic diameter(LVEDD), end systolic diameter(LVESD), ejection fraction (EF), determination of plasma BNP, endothelin (ET) and nitric oxide content. And recorded before and after the treatment of safety indexes, such as blood pressure, electrocardiogram, liver and kidney function, blood rheology, blood, urine routine. A detailed record of drug adverse reactions. Result: The plasma ET, LVEDD, LVESD, NO levels were significantly reduced compared with before treatment (P<0.05), BNP levels were significantly reduced (P<0.01), ejection fraction EF were increased significantly (P<0.01). Conclusion: The heart and kidney-reinforcing formula is effective and safe.