Pancreatic carcinoma with brain metastases: case report and literature review |
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Authors: | F. G. El Kamar K. Jindal M. L. Grossbard H. H. Mizrachi P. S. Kozuch |
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Affiliation: | St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, 1000 Tenth Avenue, Suite 11 G, New York, NY 10019, USA. |
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Abstract: | The case of a patient developing multiple brain metastases from carcinoma of the exocrine pancreas has been described. A 56-year-old man with stage IV pancreatic cancer attained a clinical and radiographic response while receiving the G-FLIP chemotherapy regimen (biweekly gemcitabine, irinotecan, 5-fluorouracil, leucovorin and cisplatin). After 4 months of therapy, he developed gait imbalance and weakness in the right hand. An MRI of the brain showed multiple 1-2 mm enhancing nodules in the cerebral hemispheres and pons. A subsequent biopsy confirmed that these were pancreatic carcinoma metastases. The patient experienced a rapid deterioration in his neurological status and died 3 days after brain biopsy. Previously reported cases of brain metastases from pancreatic cancer are reviewed. |
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Keywords: | Author Keywords: Brain metastases Chemotherapy Gemcitabine Pancreatic cancer |
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