哮喘患者体质量指数与气道炎症的相关性研究

目的 哮喘患者中，体质量指数（body mass index，BMI） 是否与气道水平相关目前仍有争议。本研究试图通过研究BMI、呼出气一氧化氮（fractional exhaled nitric oxide，FeNO） 和肺功能指标，探讨BMI 与哮喘气道炎症的相关性。 方法 从我院呼吸内科2012 年1 月- 2012 年12 月门诊哮喘患者中随机抽取176 例，年龄（46.35±12.86） 岁，女性97 例，男性79 例，所有患者均测量BMI、肺功能、FeNO，按照BMI 分为正常组（83 例）、超重组（64 例） 以及肥胖组（29 例），比较不同组别之间肺功能和FeNO 差异。 结果 不同组别之间FeNO 水平和肺功能指标均无差异。BMI 与FeNO 和肺功能指标均无相关性。男性比女性FeNO 水平高，且男性BMI 水平与FeNO 相关。 结论 体质量指数并不影响哮喘患者的气道炎症和阻塞性通气功能等指标，超重或肥胖可能从其他机制影响哮喘患者的病情。

Correlation between body mass index and airway inflammation in asthma patients

Objective To study the correlation between body mass index （BMI） and airway inflammation by investigating the BMI, fractional exhaled nitric oxide （FeNO）, and pulmonary function in asthma patients. Methods One hundred and seventy-six asthma patients （97 females and 79 males） aged 46.35 ± 12.86 years admitted to our department from January 2012 to December 2012 were included in this study. Their pulmonary function, exhaled FeNO and BMI were measured. The patients were divided into normal BMI group （n=83）, overweight group （n=64） and obesity group （n=29） according to their BMI. Their pulmonary function and FeNO were compared. Results No significant difference was found in the FeNO and pulmonary function among different groups. BMI and FeNO were not related with pulmonary function. The FeNO level was significantly higher in male patients than in female patients. The BMI was related with the FeNO level in male patients. Conclusion BMI does not affect neither the airway inflammation nor the pulmonary function in asthma patients. Overweight or obesity may influence the condition in asthma patients via other mechanisms.